Options dialog - DNS - Outbound Requests
(Main window -> Options button -> DNS / Outbound Requests section)

Simple DNS Plus v. 5.0
Copyright © 1999-2008 JH Software ApS
Send outbound DNS and zone transfer requests via
Specify which IP versions (IPv4/IPv6) and from which local IP addresses outbound requests should be sent.
It can be useful to select a specific local IP address for secondary DNS servers with multiple IP addresses (multi-homed) if the primary DNS server only allows zone transfers from a specific IP address.
When both IPv4 and IPv6 are enabled, you can also enabled "Prefer IPv6 servers" to have the server attempt to resolve DNS over IPv6 whenever possible.
 
Send outbound DNS requests from port number
Specify if Simple DNS Plus should use a system assigned port number or a specific port number to send outbound requests from.
Using system assigned port number is recommended, but in some cases it may be necessary to use a specific port number to pass through strict firewalls policies.